HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Methyl [3-({[4-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)butyl][3-(dimethylamino)-2,2-dimethylpropyl]amino}methyl)phenyl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N,N,2,2-Tetramethylpropane-1,3-diamine | HCID 104477 | — |
| Reactant | (3-Bromomethyl-phenyl)-acetic acid methyl ester | HCID 10014651 | — |
| Reactant | 9-(4-Bromobutyl)-2-butoxy-8-methoxyadenine | HCID 23158511 | — |
| Product | Methyl [3-({[4-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)butyl][3-(dimethylamino)-2,2-dimethylpropyl]amino}methyl)phenyl]acetate | HCID 11642652 | — |
Reaction Steps
Using the compound obtained in Example 2-13 step (i) (350 mg), N,N,2,2-tetramethylpropane-1,3-diamine (1 ml), potassium carbonate (500 mg) and methyl [3-(bromomethyl)phenyl]acetate (200 mg), the same manner to Example 2-29 was conducted to give the titled compound as a white solid. Yield: 60 mg (13%); MS APCI+ve 570 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575180B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-6ccc340f4d4a4203bb8406b2c594ec71 |
| Source note | uspto-grants-2013_11 |