HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2036331Generated: October 29, 2026
3,4-dihydro-2H-pyran → 2,6-Dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine
https://huagongshe.com/reaction/2036331
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | 2,6-Dichloropurine | HCID 5324412 | — |
| Catalyst | p-Toluenesulfonic acid | HCID 6101 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2,6-Dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine | HCID 270265 | 102.1% |
Reaction Steps
To 2,6-dichloropurine (25.0 g) (available from, for example, Aldrich, UK) was added ethyl acetate (260 mL), followed by p-toluenesulfonic acid (0.253 g). The mixture was heated to 50° C. and then 3,4-dihydro-2H-pyran (16.8 g) was added. The reaction mixture was then heated at 50° C. for 4 hours. The reaction mixture was evaporated in vacuo to give the title compound as a yellow solid (36.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08575181B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-23c864dcd8a742fe92fadd66cacdbb0b |
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| Source note | uspto-grants-2013_11 |
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