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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2036351Generated: November 3, 2026

1,3-Dibromopropane → 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9-{3-[(tetrahydro-2-furanylmethyl)amino]propyl}-9H-purin-6-amine

https://huagongshe.com/reaction/2036351

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-DibromopropaneHCID 8001—
ReactantTetrahydrofurfurylamineHCID 253298—
Reactant2-(Butyloxy)-8-(methyloxy)-9-{3-[(tetrahydro-2-furanylmethyl)amino]propyl}-9H-purin-6-amineHCID 67211570—
ReactantHCID 178448285HCID 178448285—
Product2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9-{3-[(tetrahydro-2-furanylmethyl)amino]propyl}-9H-purin-6-amineHCID 67211502—

Reaction Steps

Prepared similarly to Intermediate 15 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-1H-purin-6-amine trifluoroacetate, 1,3-dibromopropane, and (tetrahydro-2-furanylmethyl)amine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08575181B2
Source datasetuspto-grants-2013_11
ORD IDord-9db1146f132745edb77857b2e2c0080f
Source noteuspto-grants-2013_11