HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dibromopropane → N2-Butyl-8-(methyloxy)-9-{3-[(tetrahydro-2H-pyran-4-ylmethyl)amino]propyl}-9H-purine-2,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dibromopropane | HCID 8001 | — |
| Reactant | 4-Aminomethyltetrahydropyran | HCID 2773210 | — |
| Reactant | 2-(Butyloxy)-8-(methyloxy)-9-{3-[(tetrahydro-2-furanylmethyl)amino]propyl}-9H-purin-6-amine | HCID 67211570 | — |
| Reactant | HCID 178448879 | HCID 178448879 | — |
| Product | N2-Butyl-8-(methyloxy)-9-{3-[(tetrahydro-2H-pyran-4-ylmethyl)amino]propyl}-9H-purine-2,6-diamine | HCID 67211768 | — |
Reaction Steps
Prepared similarly to Intermediate 15 from N2-butyl-8-methoxy-9H-purine-2,6-diamine trifluoroacetic acid salt, 1,3-dibromopropane, and (tetrahydro-2H-pyran-4-ylmethyl)amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575181B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-211a7e965724423da8ed2b4d3fe58796 |
| Source note | uspto-grants-2013_11 |