HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminomethyltetrahydropyran → 2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-{4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]butyl}-9H-purin-6-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminomethyltetrahydropyran | HCID 2773210 | — |
| Reactant | 9-(4-Chlorobutyl)-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine | HCID 58290933 | — |
| Reactant | 2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[4-(tetrahydro-2H-pyran-4-ylamino)butyl]-9H-purin-6-amine | HCID 58290934 | — |
| Product | 2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-{4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]butyl}-9H-purin-6-amine | HCID 58290947 | — |
Reaction Steps
Prepared similarly to Intermediate 36 from 9-(4-chlorobutyl)-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine and (tetrahydro-2H-pyran-4-ylmethyl)amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575181B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-6767211458014281b15b6720a97d763b |
| Source note | uspto-grants-2013_11 |