HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2036363Generated: October 26, 2026
(R)-3-Aminotetrahydrofuran → 2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-{4-[(3R)-tetrahydro-3-furanylamino]butyl}-9H-purin-6-amine
https://huagongshe.com/reaction/2036363
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (R)-3-Aminotetrahydrofuran | HCID 10996958 | — |
| Reactant | 9-(4-Chlorobutyl)-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine | HCID 58290933 | — |
| Reactant | 2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[4-(tetrahydro-2H-pyran-4-ylamino)butyl]-9H-purin-6-amine | HCID 58290934 | — |
| Product | 2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-{4-[(3R)-tetrahydro-3-furanylamino]butyl}-9H-purin-6-amine | HCID 58290959 | — |
Reaction Steps
Prepared similarly to Intermediate 36 from 9-(4-chlorobutyl)-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine and (3R)-tetrahydro-3-furanamine but with heating at 70° C. for an additional 20 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08575181B2 |
|---|
| Source dataset | uspto-grants-2013_11 |
|---|
| ORD ID | ord-a49b727e61cd492bb741f1d5910fdc77 |
|---|
| Source note | uspto-grants-2013_11 |
|---|
