HCID 68559585, compound → 5-(R)-[2-(S)-Amino-3-(3,5-difluorophenyl)-1-(S)-hydroxypropyl]-2-(S)-(2-cyclohexylethyl)-morpholine-4-carboxylic acid tert-butyl ester

Participants

Reaction Steps

Add 20% palladium hydroxide on carbon (Pearlman's catalyst) (232 mg) to a solution of 5-(R)-[1-(S)-benzyloxy-2-(S)-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-(S)-(2-cyclohexylethyl)-morpholine-4-carboxylic acid tert-butyl ester (232 mg, 0.31 mmol) in methanol (5 mL). Stir under 1 atmosphere of hydrogen gas at room temperature overnight, filter through a pad of Celite® and concentrate to give the desired compound as a colorless oil which is used directly without further purification (138 mg, 93%).

Provenance & Evidence