反应详情

4,6-Dichloro-5-pyrimidinecarbaldehyde oxime (8 g) was dissolved in CHCl3 (40 mL) and treated with SOCl2 (6 mL) for 2 h at rt. The solvent was removed and the residue triturated with DCM (5 mL) to give a white solid, which was filtered and washed with DCM (5 mL). The filtrate was concentrated under reduced pressure and purified by column chromatography on silica gel (dry loading, DCM/hexane, 3/1) to give a white solid. The two solids were combined to provide 4,6-dichloro-5-pyrimidinecarbonitrile.

1. customThe solvent was removed
2. customthe residue triturated with DCM (5 mL)
3. customto give a white solid, which
4. filtrationwas filtered
5. washwashed with DCM (5 mL)
6. concentrationThe filtrate was concentrated under reduced pressure
7. custompurified by column chromatography on silica gel (dry loading, DCM/hexane, 3/1)
8. customto give a white solid