4-Fluoroaniline → HCID 54527561, compound

HRID 2036563Notes

Reaction equation

HRID 2036563 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[F:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][CH:14]=1>>[F:8][C:6]1[CH:5]=[CH:4][C:3]([N+:9]([O-:11])=[O:10])=[C:2]([CH:7]=1)[NH:17][C:16]1[CH:18]=[CH:19][C:13]([F:12])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 97314-FluoroanilineHCID 679672,4-Difluoronitrobenzene

Product 1

HCID 54527561HCID 54527561, compound

Procedure

Prepared according to Step D1 in General Procedure D using 2,4-difluoronitro-benzene (2.068 mL, 18.86 mmol) and 4-fluoroaniline (1.811 mL, 18.86 mmol) to give 5-fluoro-N-(4-fluorophenyl)-2-nitroaniline as an orange solid: 1H NMR (400 MHz, DMSO-d6) δ ppm 9.56 (1H, s), 8.24 (1H, dd, J=9.5, 6.2 Hz), 7.36-7.44 (2H, m), 7.25-7.33 (2H, m), 6.67-6.74 (1H, m), 6.64 (1H, dd, J=11.8, 2.6 Hz); LC-MS (ESI) m/z 251.1 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e820ba250ccf4c90a40894e5d02e218f
Source dataset
uspto-grants-2013_11
Patent number
US08575183B2

Reaction notes

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