Tetrahydrofuran → HCID 58459243, compound

Participants

Reaction Steps

To a mixture of N-(1-(6-fluoro-1-(2-(methylthio)phenyl)-1H-benzo[d]imidazol-2-yl)ethyl)acetamide (1.1697 g, 3.41 mmol) in THF (25.5 mL) and water (8.52 mL) was added oxone (5.23 g, 8.52 mmol) and the mixture was stirred at rt. After 48 h, to the mixture was added water (50 mL), extracted with DCM (50 mL×2). The combined organic layers were dried over Na2SO4, filtered, combined with the white solid, and concentrated under reduced pressure to give N-(1-(6-fluoro-1-(2-(methylsulfonyl)phenyl)-1H-benzo[d]imidazol-2-yl)ethyl)acetamide as an orange solid: LC-MS (ESI) m/z 376.0 [M+H]+. The orange solid was carried on crude without purification.

Provenance & Evidence