Sodium Carbonate → 2-((1S)-1-((6-amino-5-(4-(methylsulfonyl)phenyl)-4-pyrimidinyl)amino)ethyl)-1-cyclopropyl-N-methyl-1H-benzimidazole-7-carboxamide

Participants

Reaction Conditions

Reaction Steps

A mixture of (S)-2-(1-(6-amino-5-iodopyrimidin-4-ylamino)ethyl)-1-cyclopropyl-N-methyl-1H-benzo[d]imidazole-7-carboxamide (Prepared in Example 20, 50.4 mg, 0.106 mmol), 1,1′-bis(diphenylphosphino)ferrocene-palladium dichloride (17.25 mg, 0.021 mmol), Na2CO3 (0.026 ml, 0.634 mmol), 4-(methanesulfonyl)-benzeneboronic acid (52.8 mg, 0.264 mmol) in anhydrous 1,2-dimethoxyethane (5 mL) and water (1 mL) was heated to 80° C. under N2. After 1 h, the mixture was cooled to rt and filtered. The filtrate was concentrated under reduced pressure, and purified by column chromatography on a silica gel column using 0 to 10% gradient of MeOH in DCM-EtOAc (1:1) as eluent to give 2-((1S)-1-((6-amino-5-(4-(methylsulfonyl)phenyl)-4-pyrimidinyl)amino)ethyl)-1-cyclopropyl-N-methyl-1H-benzimidazole-7-carboxamide: 1H NMR (400 MHz, DMSO-d6) δ 8.42-8.37 (m, 1H), 8.06 (d, J=8 Hz, 2H), 8.01 (s, 1H), 7.61 (d, J=8 Hz, 2H), 7.56 (d, J=8 Hz, 1H), 7.20 (d, J=8 Hz, 1H), 7.15 (dd, J=8, 8 Hz, 1H), 5.85-5.75 (m, 2H), 3.28 (s, 3H), 2.83 (d, J=4 Hz, 3H), 1.49 (d, J=8 Hz, 3H), 1.18-1.08 (m, 2H), 0.98-0.92 (m, 1H), 0.83-0.75 (m, 1H); LC-MS (ESI) m/z 506.0 [M+H]+.

Provenance & Evidence