反应详情

The crude 2-(cyclopropylamino)-3-nitrobenzoic acid (0.90 g, 4.1 mmol) was dissolved in MeOH (15 mL), and 2 mL H2SO4 (98%) was added. The mixture was heated to reflux for 18 h. The mixture was cooled, concentrated in vacuo, and purified by column chromatography on a silica gel column using DCM as eluent to give methyl 2-(cyclopropylamino)-3-nitrobenzoate: LC-MS (ESI) m/z 237.1 [M+H]+.

1. temperatureThe mixture was heated
2. temperatureto reflux for 18 h
3. temperatureThe mixture was cooled
4. concentrationconcentrated in vacuo
5. custompurified by column chromatography on a silica gel column