Lithium iodide → HCID 58459203, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (S)-methyl 2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-1-cyclopropyl-1H-benzo[d]imidazole-7-carboxylate (137 mg, 0.36 mmol) and lithium iodide (146 mg, 1.1 mmol) in pyridine (5 mL) was heated to reflux at 100° C. for 48 h. Another portion of lithium iodide (146 mg, 1.1 mmol) was added and the mixture was heated at 100° C. for another 48 h. The mixture was concentrated in vacuo, and subjected to the next reaction without further purification: LC-MS (ESI) m/z 364.1 [M+H]+.

Provenance & Evidence