Sodium Bicarbonate → HCID 58459321, compound

Participants

Reaction Steps

A solution of tert-butyl-1-(1-(3,5-difluorophenyl)-4,6-difluoro-1H-benzo[d]imidazol-2-yl)ethylcarbamate (0.4 g) was stirred in 2 N HCl (4 mL) at 120° C. for 4 h. The reaction mixture was cooled to rt and basified with satd. sodium bicarbonate solution (20 mL). The organic layer was extracted with EtOAc, dried over sodium sulfate and concentrated in vacuo to provide 1-(1-(3,5-difluorophenyl)-4,6-difluoro-1H-benzo[d]imidazol-2-yl]-ethanamine. The crude product was carried on without further purification.

Provenance & Evidence