HCID 58459119, compound → HCID 58459244, compound

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Reaction Steps

Using the general synthetic procedure for (S)-methyl 2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-1-cyclopropyl-1H-benzo[d]imidazole-7-carboxylate in example 47, 2-((1S)-1-((6-amino-5-cyano-4-pyrimidinyl)amino)ethyl)-N-tert-butyl-1-cyclopropyl-1H-benzimidazole-7-carboxamidewas prepared using (S)-2-(1-amino ethyl)-N-tert-butyl-1-cyclopropyl-1H-benzo[d]imidazole-7-carboxamide: 1H NMR (400 MHz, MeOH-d4) δ 8.03 (1H, s), 7.68 (1H, d, J=8.0 Hz), 7.38 (1H, d, J=8.0 Hz), 7.27 (1H, t, J=8.0 Hz), 6.04 (1H, q, J=8.0 Hz), 3.55-3.43 (1H, m), 3.03-2.96 (1H, m), 1.73 (3H, d, J=4.0 Hz), 1.53 (9H, s), 1.40-1.30 (1H, m), 1.30-1.15 (2H, m), 1.10-0.93 (1H, m); LC-MS (ESI) m/z 419.2 [M+H]+.

Provenance & Evidence