Water → HCID 67434358, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-(3,5-difluorophenyl)-3-nitro-pyridin-2-amine (2.0 g, 7.96 mmol) in AcOH (24 mL) was added iron powder (1.33 g, 23.8 mmol) and the reaction mixture was heated to 100° C. for 1 h. The reaction mixture was cooled to rt and water (70 mL) was added. The organic layer was extracted with EtOAc (350 mL) and was basified by using satd. sodium bicarbonate solution (150 mL), dried over sodium sulfate and concentrated in vacuo to provide N1-(3,5-Difluorophenyl)-pyridine-2,3-diamine. The crude product was used without further purification.

Provenance & Evidence