Sodium Bicarbonate → HCID 58459253, compound

Participants

Reaction Steps

A solution of (S)-tert-butyl-1-(2-(3,5-difluorophenylamino)pyridine-3-ylamino)-1-oxopropan-2-ylcarbamate (1.7 g, 4.33 mmol) in AcOH (12 mL) was stirred at 100° C. overnight. After completion of the reaction the mixture was cooled to rt and basified with satd. sodium bicarbonate solution (60 mL). The organic layer was then extracted with EtOAc (150 mL), dried over sodium sulfate an concentrated in vacuo to provide tert-butyl 1-(3-(3,5-Difluorophenyl)-3H-imidazo[4,5-b]pyridin-2-yl)-ethylcarbamate. The crude product was used without further purification.

Provenance & Evidence