HCID 67431176, compound → HCID 58459169, compound

Participants

Reaction Conditions

Reaction Steps

A crude mixture of {{1-[1-(3,5-difluorophenyl)-1H-imidazo[4,5-b]pyridin-2-yl]-ethyl}-carbamic acid tert-butyl ester and N-{1-[1-(3,5-difluorophenyl)-1H-imidazo[4,5-b]pyridin-2-yl]-ethyl}-acetamide (300 mg) was suspended in methanolic HCl (3 mL). The reaction mixture was stirred at 70° C. for 12 h. After completion of the reaction, the solvent was removed under vacuum. The residue was suspended in water and basified using satd sodium bicarbonate solution and extracted with EtOAc. The organic layer was dried over sodium sulfate and concentrated in vacuo to provide 1-[1-(3,5-difluorophenyl)-1H-imidazo[4,5-b]pyridin-2-yl]-ethylamine: LC-MS (ESI) m/z 275.1 [M+H]+. The crude product was used without further purification.

Provenance & Evidence