N-Iodosuccinimide → [1-(3-Iodo-imidazo[1,2-a]pyrimidin-2-yl)-ethyl]-carbamic acid benzyl ester

Participants

Reaction Steps

To a solution of (1-imidazo[1,2-a]pyrimidin-2-yl-ethyl)-carbamic acid benzyl ester (5.3 g, 17.90 mmol) in acetonitrile (30 mL) was added n-iodosuccinimide (4.0 g, 17.90 mmol) and stirred at rt overnight. After completion of the reaction, the mixture was diluted with water and extracted with EtOAc. The organic layer was washed with satd. sodium bicarbonate solution, dried over sodium sulfate, filtered and concentrated in vacuo. The crude product was purified by column chromatography using silica gel (100-200 mesh) and 0-4% MeOH in DCM to provide [1-(3-iodo-imidazo[1,2-a]pyrimidin-2-yl)-ethyl]-carbamic acid benzyl ester: LC-MS (ESI) m/z 422.8 [M+H]+.

Provenance & Evidence