Pyridine → HCID 58459378, compound

Participants

Reaction Steps

A solution of methyl 2-((1S)-1-(6-amino-5-cyano-4-pyrimidinyl)amino)ethyl)-3-(5-fluoro-3-pyridinyl)imidazo[1,2-a]pyridine-5-carboxylate (0.060 g, 0.139 mmol) and lithium iodide (0.056 g, 0.416 mmol) in pyridine (0.73 mL) was stirred at 100° C. for 6 h. Volatiles were removed under reduced pressure to afford (S)-2-(1-((3-amino-2-cyanophenyl)amino)ethyl)-3-(5-fluoropyridin-3-yl)imidazo[1,2-a]pyridine-5-carboxylic acid as a dark residue. LC-MS (ESI) m/z 419.1 [M+H]+.

Provenance & Evidence