Dimethyl Sulfide → HCID 58459106, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of (S)-methyl 2-(1-(((benzyloxy)carbonyl)amino)ethyl)-3-phenylimidazo[1,2-a]pyridine-5-carboxylate (600 mg, 1.3 mmol) and dimethylsulfide (0.4 mL) in TFA (1.2 mL) was stirred at 25° C. overnight. The mixture was concentrated in vacuo and the residue was dissolved in EtOAc. The organic layer was washed with satd. sodium bicarbonate, dried over sodium sulfate, filtered and concentrated in vacuo to provide (S)-methyl 2-(1-aminoethyl)-3-phenylimidazo-[1,2-a]pyridine-5-carboxylate (400 mg): LC-MS (ESI) m/z 296.2 [M+H]+. The crude product was used without further purification.

Provenance & Evidence