Dimethyl Sulfide → HCID 58459336, compound

Participants

Reaction Steps

The mixture of (S)-methyl 2-(1-(((benzyloxy)carbonyl)amino)ethyl)-3-(pyridin-3-yl)imidazo[1,2-a]pyridine-5-carboxylate (450 mg, 1.04 mmol) and dimethylsulfide (0.4 mL) in TFA (1.2 mL)) was stirred at rt overnight. The mixture was concentrated in vacuo. The residue was dissolved in EtOAc. The organic layer was washed with satd. sodium bicarbonate solution, dried over sodium sulfate, filtered and concentrated in vacuo to provide (S)-methyl 2-(1-aminoethyl)-3-(pyridin-3-yl)imidazo[1,2-a]pyridine-5-carboxylate: LC-MS (ESI) m/z 297.2 [M+H]+. The crude product was used without further purification.

Provenance & Evidence