Cesium carbonate → HCID 67431344, compound

Participants

Reaction Conditions

Reaction Steps

To a microwave vial was added cesium carbonate (1.30 g, 3.98 mmol), Pd2(dba)3 (0.146 g, 0.159 mmol), Xantphos (0.230 g, 0.398 mmol), N-(1-(1-(5-bromopyridin-3-yl)-6-fluoro-1H-benzo[d]imidazol-2-yl)ethyl)acetamide (0.600 g, 1.59 mmol), and methanesulfonamide (0.166 g, 1.75 mmol) in dioxane (7.95 mL). The suspension was purged with nitrogen for 5 min then was stirred at 120° C. for 3 h under microwave irradiation. The solution was loaded directly onto silica gel then purified by MPLC (eluted with a gradient of 0-10% MeOH in DCM) to afford N-(1-(6-fluoro-1-(5-(methylsulfonamido)pyridin-3-yl)-1H-benzo[d]imidazol-2-yl)ethyl)acetamide as an off-white solid. LC-MS (ESI) m/z 392.1 [M+H]+.

Provenance & Evidence