Trifluoroacetic acid → HCID 87262770, compound

Participants

Reaction Steps

The product of step A was subjected to Boc-deprotection with TFA following the procedure of Example 28, step B. The crude material was purified by flash column chromatography (SiO2, 9:1 dichloromethane/methanol) to give 2-(3-trifluoromethylphenyl)sulfonyl-5-methyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole trifluoroacetate (130 mg, 95%) as a white solid: 1H NMR (CDCl3, 300 MHz) δ 8.20 (s, 1H), 8.10-8.14 (m, 2H), 7.57-7.78 (m, 3H), 7.33 (d, J=8.7 Hz 1H), 4.89 (d, J=4.5 Hz, 1H), 4.30-4.34 (m, 1H), 3.60 (s, 3H), 3.40 (dd, J=12.0, 4.5 Hz, 1H), 2.65 (d, J=16.8 Hz, 1H), 2.30-2.39 (m, 2H), 2.08-2.16 (m, 1H), 1.66-1.72 (m, 1H).

Provenance & Evidence