HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 20367Generated: October 29, 2026
2-Amino-3-(benzyloxy)propan-1-ol → 1-(1-(R)-benzyloxymethyl-2-hydroxyethylamino)-4-cyclohexylbutan-2-(S)-ol
https://huagongshe.com/reaction/20367
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Amino-3-(benzyloxy)propan-1-ol | HCID 14118408 | — |
| Reactant | 2-(S)-(2-cyclohexylethyl)-oxirane | HCID 86615360 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(1-(R)-benzyloxymethyl-2-hydroxyethylamino)-4-cyclohexylbutan-2-(S)-ol | HCID 68564125 | 57.2% |
Reaction Steps
Dissolve (R)-(+)-2-amino-3-benzyloxy-1-propanol (317 mg, 1.75 mmol) and 2-(S)-(2-cyclohexylethyl)-oxirane (270 mg, 1.75 mmol) in absolute ethanol (8 mL) and heat at 80° C. in a sealed glass pressure vessel overnight. Concentrate and purify (silica gel chromatography, eluting with 8:92 to 10:90 methanol:dichloromethane) to give the desired compound (336 mg, 57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07745438B2 |
|---|
| Source dataset | uspto-grants-2010_06 |
|---|
| ORD ID | ord-0dd0f2b0bb82455580b3219019ff4366 |
|---|
| Source note | uspto-grants-2010_06 |
|---|
