HCID 23717243, compound → HCID 67085605, compound

Participants

Reaction Steps

Intermediate 7 was coupled with the product of Example 27, step B following the procedure of Example 27, step C. The crude product was purified by flash column chromatography (SiO2, 7:3 hexanes/ethyl acetate) to give tert-butyl 2-(3-methoxyphenyl)sulfonyl-5-methyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-carboxylate (194 mg, 63%) as an off-white solid: 1H NMR (CDCl3, 300 MHz) δ 8.19 (s, 1H), 7.67 (d, J=8.1 Hz, 1H), 7.47-7.52 (m, 2H), 7.26-7.37 (m, 2H), 6.98-7.08 (m, 1H), 5.25-5.29 (m, 1H), 4.70 (br s, 1H), 3.82 (s, 3H), 3.60 (s, 3H), 3.36-3.49 (m, 1H), 2.49 (d, J=16.0 Hz, 1H), 2.25-2.33 (m, 1H), 2.16-2.23 (m, 1H), 1.90-1.97 (m, 1H), 1.50-1.70 (m, 1H), 1.37 (s, 9H).

Provenance & Evidence