15898-46-1 → HCID 67085522, compound

Participants

Reaction Steps

Intermediate 8 was coupled with the product of Example 27, step B following the procedure of Example 27, step C. The crude material was purified by flash column chromatography (SiO2, 3:2 hexane/ethyl acetate) to give tert-butyl 2-(3-nitrophenylsulfonyl)-5-methyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-carboxylate (50 mg, 13%) as a yellow solid: 1H NMR (CDCl3, 300 MHz) δ 8.76 (s, 1H), 8.25-8.38 (m, 1H), 8.21 (s, 1H), 7.67-7.72 (m, 2H), 7.65 (s, 1H), 7.35 d, J=8.7 Hz, 1H), 5.27 (br s, 1H) 4.70-4.73 (m, 1H), 3.62 (s, 3H), 3.38-3.42 (m, 1H), 2.51 (d, J=15 Hz, 1H), 2.15-2.42 (m, 2H), 1.97-1.90 (m, 1H), 1.54-1.67 (m, 1H), 1.37 (s, 9H).

Provenance & Evidence