HCID 23675619, compound → HCID 67085645, compound

Participants

Reaction Steps

Intermediate 24 was coupled with the product of Example 27, step B following the procedure of Example 27, step C. The crude material was purified by flash column chromatography (SiO2, 8:2 hexanes/ethyl acetate) to give tert-butyl 2-(2-napthyl)sulfonyl-5-methyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-carboxylate (113 mg, 24%) as a light-yellow solid: 1H NMR (CDCl3, 300 MHz) δ 8.58 (d, J=0.9 Hz, 1H), 8.26 (s, 1H), 7.93-8.04 (m, 1H), 7.81-7.88 (m, 2H), 7.71 (d, J=9.9 Hz, 1H), 7.52-7.63 (m, 2H), 7.42-7.51 (m, 1H), 7.29 (d, J=8.7 Hz, 1H), 5.26 (br s, 1H), 4.71 (br s, 1H), 3.59 (s, 3H), 3.39 (br s, 1H), 2.49 (d, J=16.2 Hz, 1H), 2.20-2.48 (m, 2H), 1.88-1.99 (m, 1H), 1.59-1.67 (m, 1H), 1.37 (br s, 9H).

Provenance & Evidence