HCID 50998759, compound → HCID 67173587, compound

Participants

Reaction Steps

Intermediate 21 was coupled with the product of Example 27, step B following the procedure of Example 27, step C. The crude product was purified by flash column chromatography (SiO2, 8:2 hexanes/ethyl acetate) to give tert-butyl 2-(3,5-difluorophenyl)sulfonyl-5-methyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-carboxylate (40 mg, 13%) as an off-white solid: 1H NMR (CDCl3, 300 MHz) δ 8.17 (s, 1H), 7.67 (d, J=8.7 Hz, 1H), 7.44-7.50 (m, 2H), 7.34 (d, J=8.7 Hz, 1H), 6.91-6.96 (m, 1H), 5.26 (br s, 1H), 4.71 (br s, 1H), 3.62 (s, 3H), 3.39 (br s, 1H), 2.48 (d, J=16.0 Hz, 1H), 2.18-2.35 (m, 2H), 1.91-1.99 (m, 1H), 1.50-1.68 (m, 1H), 1.37 (s, 9H)

Provenance & Evidence