HCID 58258876, compound → HCID 67085203, compound

Participants

Reaction Steps

Intermediate 25 was coupled with the product of Example 27, step B following the procedure of Example 27, step C. The crude material was purified by flash column chromatography (SiO2, hexane/ethyl acetate 55:45) to give tert-butyl 2-(3-thienyl)sulfonyl-5-methyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-carboxylate (130 mg, 31%) as a yellow solid: 1H NMR (CDCl3, 300 MHz) δ 8.20 (s, 1H), 8.02-8.53 (m, 1H), 7.66-7.74 (m, 1H), 7.28-7.37 (m, 3H), 5.26 (br s, 1H), 4.70 (br s, 1H), 3.61 (s, 3H), 3.38 (br s, 1H), 2.50 (d, J=15.9 Hz, 1H), 2.12-2.41 (m, 2H), 1.89-2.00 (m, 1H), 1.57-1.68 (m, 1H), 1.48 (s, 9H).

Provenance & Evidence