Hydrochloric Acid → HCID 57392614, compound

Participants

Reaction Steps

The product of step A was subjected to Boc-deprotection with 2 M HCl in diethyl ether following the procedure of Example 28, step B. The crude material was purified by flash column chromatography (SiO2, 88:12 chloroform/methanol) to give 2-(3-thienyl)sulfonyl-5-methyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole (84 mg, 83%) as a yellow solid: 1H NMR (CDCl3, 300 MHz) δ 8.18 (d, J=1.8 Hz, 1H), 8.00-8.05 (m, 1H), 7.68 (dd, J=8.7, 1.8 Hz, 1H), 7.28-7.35 (m, 3H), 4.60 (d, J=5.1 Hz, 1H), 4.05-4.15 (m, 1H), 3.60 (s, 3H), 3.17 (dd, J=16.5, 4.5 Hz, 1H), 2.53 (d, J=16.5 Hz, 1H), 1.95-2.29 (m, 3H), 1.51-1.65 (m, 1H).

Provenance & Evidence