Diphenyl sulfone → HCID 67085359, compound

Participants

Reaction Steps

The product of step C was converted to the phenylsulfone derivative following the procedure of Example 71, step D. The crude product was purified by flash column chromatography (SiO2, 75:25 hexane/ethyl acetate) to give tert-butyl 2-phenylsulfonyl-4-fluoro-5-methyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-carboxylate (61 mg, 26%) as an off-white solid: 1H NMR (CDCl3, 300 MHz): δ 7.91-7.99 (m, 3H), 7.43-7.55 (m, 3H), 7.28-7.36 (m, 1H), 5.13-5.31 (m, 1H), 4.58-4.70 (m, 1H), 3.78 (s, 3H), 3.14-3.50 (m, 1H), 2.41 (d, J=19.2 Hz, 1H), 2.12-2.40 (m, 2H), 1.86-1.97 (m, 1H), 1.58-1.68 (m, 1H), 1.38 (br s, 9H).

Provenance & Evidence