Hydrochloric Acid → HCID 67085200, compound

Participants

Reaction Steps

The product of step B (100 mg, 0.26 mmol) was treated with 1.25 M HCl in methanol (2 mL). The solution was concentrated in vacuo and lyophilized from water to give 2-phenylsulfonyl-5-(2-hydroxy)ethyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole hydrochloride (90 mg, 74%, AUC HPLC >99%) as a white solid: mp 185-190° C.; 1H NMR (CD3OD, 300 MHz) δ 8.26 (s, 1H), 7.93-7.96 (m, 2H), 7.71 (dd, J=8.8, 1.8 Hz, 1H), 7.51-7.62 (m, 4H), 5.25-5.26 (m, 1H), 4.49 (br s, 1H), 4.24 (t, J=5.1 Hz, 2H), 3.80 (t, J=5.1 Hz, 2H), 3.48-3.53 (m, 1H), 3.10 (d, J=18.0 Hz, 1H), 2.23-2.44 (m, 3H), 1.91-1.96 (m, 1H); ESI, m/z 383 [M+H]+.

Provenance & Evidence