3-Chloro-4-fluoroaniline → 2-(3-Chloro-4-fluoro-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide

HRID 203681Notes

Reaction equation

HRID 203681 reaction equation
[CH:1]1([CH2:6][NH:7][C:8](=[O:9])[c:10]2[c:11]([C:17]([F:18])([F:19])[F:20])[n:12][c:13]([Cl:16])[n:14][cH:15]2)[CH2:2][CH2:3][CH2:4][CH2:5]1.[Cl:21][c:22]1[cH:23][c:24]([NH2:25])[cH:26][cH:27][c:28]1[F:29].[O:30]1[CH2:31][CH2:32][O:33][CH2:34][CH2:35]1>>[CH:1]1([CH2:6][NH:7][C:8](=[O:9])[c:10]2[c:11]([C:17]([F:18])([F:19])[F:20])[n:12][c:13]([NH:25][c:24]3[cH:23][c:22]([Cl:21])[c:28]([F:29])[cH:27][cH:26]3)[n:14][cH:15]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 3

HCID 97083-Chloro-4-fluoroanilineHCID 312751,4-DioxaneHCID 579826072-Chloro trifluoromethyl-pyrimidin-5-carboxylic acid (cyclopentylmethyl)-amide

Product 1

HCID 579826572-(3-Chloro-4-fluoro-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide

Sources & evidence

ORD record
ord-4f420d7839dc483b87e2143bd1613475
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…