Ammonia → HCID 67055948, compound

HRID 2036820Notes

Reaction equation

HRID 2036820 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([S:8]([CH2:11][C:12]([O:14]C)=O)(=[O:10])=[O:9])[CH:5]=[N:6][CH:7]=1.[NH3:16]>CO>[Br:1][C:2]1[CH:3]=[C:4]([S:8]([CH2:11][C:12]([NH2:16])=[O:14])(=[O:10])=[O:9])[CH:5]=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 67055863HCID 67055863, compound

Product 1

HCID 67055948HCID 67055948, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of methyl 2-(5-bromopyridin-3-ylsulfonyl)acetate (0.2 g, 0.67 mmol) was added 5% ammonia in methanol (10 mL). Upon completion of addition, the reaction mixture was stirred at 60° C. for 4 h. After this time, the reaction mixture was allowed to cool to room temperature. Once at the prescribed temperature, the reaction mixture was concentrated under reduced pressure to afford 2-(5-bromopyridin-3-ylsulfonyl)acetamide (0.2 g) as a white solid. LCMS Method W: retention time 0.92 min; [M−1]=277.0.

Workup

  1. additionUpon completion of addition
  2. temperatureto cool to room temperature
  3. concentrationOnce at the prescribed temperature, the reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-aae13e850c9d45af82e31289bc580ebe
Source dataset
uspto-grants-2013_11
Patent number
US08575184B2

Reaction notes

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