反应详情

温度

80 °C

To a solution 3-(1-cyanocyclopropanecarboxamido)biphenyl-2-carboxamide (0.7 g, 2 mmol) in methanol was added saturated aqueous Na2CO3 (23 mmol) and the reaction mixture stirred at 80° C. for 30 min. The reaction mixture was concentrated under reduced pressure and the resulting residue was diluted with ethyl acetate then washed with water. The organic extracts were dried, concentrated and purified by silica gel chromatography (4% MeOH in DCM) to yield 1-(4-oxo-5-phenyl-3,4-dihydroquinazolin-2-yl)cyclopropanecarbonitrile (0.65 g, 99% yield) as a white solid. LCMS Method T: retention time 1.810 min; [M+1]=288.2.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additionthe resulting residue was diluted with ethyl acetate
3. washthen washed with water
4. customThe organic extracts were dried
5. concentrationconcentrated
6. custompurified by silica gel chromatography (4% MeOH in DCM)