HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-Hydroxy-2-(pyridin-2-ylacetyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-(pyridin-2-ylacetyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide | HCID 86656591 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-Hydroxy-2-(pyridin-2-ylacetyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide hydrochloride | HCID 86656590 | — |
Reaction Steps
A mixture of 75 mg 2-(pyridin-2-ylacetyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide and 6 ml of a 0.1M solution of HCl in water in 4 ml methanol is stirred overnight at ambient temperature and evaporated. The mixture is dissolved in a mixture of 2 ml water and 2 ml acetonitrile and lyophilized. 75 mg of the title compound are obtained as colorless solid. MH+=312.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575193B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-bd2d9efed3324f2f9ebaeb57958f7ab3 |
| Source note | uspto-grants-2013_11 |