HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-Hydroxy-2-(1H-indol-3-ylacetyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 86656607 | HCID 86656607 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-Hydroxy-2-(1H-indol-3-ylacetyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide | HCID 44229353 | 63.4% |
Reaction Steps
A mixture of 180 mg 2-(1H-indol-3-ylacetyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide, 6 ml methanol and 6 ml 0.1 N aqueous hydrochloric acid are stirred at ambient temperature overnight. The reaction mixture is evaporated and the residue is dissolved in a mixture of acetonitrile and water and lyophilized. 92 mg of the title compound are obtained. MH+=350.0
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575193B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-94c189c322b34180bbd0b7e10befd700 |
| Source note | uspto-grants-2013_11 |