HCID 86656615, compound → HCID 44229429, compound

Participants

Reaction Steps

A mixture of 207 mg 2-[(5-methoxy-1H-indol-2-yl)carbonyl]-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide in 6 ml methanol and 6 ml 0.1 N aqueous hydrochloric acid is stirred overnight at ambient temperature. Subsequently, the reaction mixture is evaporated. The residue is treated with 10 ml methanol at 60° C. for 1 h. The resulting solid is collected and dried. 43 mg of the title compound are obtained as colorless solid. MH+=365.0

Provenance & Evidence