1,2-Dichloroethane → HCID 86656605, compound

Participants

Reaction Steps

A mixture of 200 mg N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide, 0.063 ml cyclopropylcarboxylic acid, 111 mg HOBt, 276 mg EDC, 0.603 ml triethylamine and 7 ml DMF is stirred overnight at ambient temperature. The reaction mixture is evaporated. The residue is then purified by silica gel chromatography. 91 mg of the title compound are obtained.

Provenance & Evidence