Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2036958생성일: 2026년 10월 26일
Hydrochloric Acid → Tert-butyl 3-(5-(3-chlorophenylamino)pyrazolo[1,5-a]pyrimidin-7-ylamino)benzoate
https://huagongshe.com/reaction/2036958
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 3-Chloroaniline | HCID 7932 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | Tert-butyl 3-(5-chloropyrazolo[1,5-a]pyrimidin-7-ylamino)benzoate | HCID 58314667 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | tert-Butanol | HCID 6386 | — |
| 생성물 | Tert-butyl 3-(5-(3-chlorophenylamino)pyrazolo[1,5-a]pyrimidin-7-ylamino)benzoate | HCID 58314302 | 55% |
반응 단계
To the reaction flask, tert-butyl 3-(5-chloropyrazolo[1,5-a]pyrimidin-7-ylamino)benzoate (2.9 g, 8.2 mmol) was added along with 3-chloroaniline (2.2 mL, 20.6 mmol), 4N HCl in dioxane (2.6 mL, 10.4 mmol), and t-butyl alcohol (41 mL). The reaction was stirred at 100° C. for 2 days then cooled to room temperature. The mixture was diluted with water, made basic with 3N NaOH, filtered and washed with water. The product, tert-butyl 3-(5-(3-chlorophenylamino)pyrazolo[1,5-a]pyrimidin-7-ylamino)benzoate, was collected as a solid in 55% yield after drying under vacuum overnight. LCMS (M+1=436)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08575177B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_11 |
|---|
| ORD ID | ord-422ecdcd437b44e39253648f4e7f5078 |
|---|
| 출처 메모 | uspto-grants-2013_11 |
|---|
