Triethylamine → 5-chloro-N-cyclopropylpyrazolo[1,5-a]pyrimidin-7-amine

https://huagongshe.com/reaction/2036991

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	Cyclopropylamine	HCID 69828	—
Reactant	5,7-Dichloropyrazolo[1,5-a]pyrimidine	HCID 11074154	—
Solvent	Acetonitrile	HCID 6342	—
Product	5-chloro-N-cyclopropylpyrazolo[1,5-a]pyrimidin-7-amine	HCID 58196606	70.5%

Reaction Conditions

Temperature	80 °C

Reaction Steps

To 5,7-dichloropyrazolo[1,5-a]pyrimidine (200 mg, 1.06 mmol) in acetonitrile was added Et3N (148 μl, 1.06 mmol) and cyclopropylamine (75 μl, 1.06 mmol). The reaction was heated at 80° C. overnight. The mixture was concentrated under reduced pressure, dissolved in dichloromethane, and washed with water. The resulting organic layer was dried over Na2SO4 and concentrated under reduced pressure to afford 156 mg of 5-chloro-N-cyclopropylpyrazolo[1,5-a]pyrimidin-7-amine (70% yield). LCMS (M+1=209)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08575177B2
Source dataset	uspto-grants-2013_11
ORD ID	ord-7cb31d3713c34329aabcfea75bd1457f
Source note	uspto-grants-2013_11