HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Isocyanatothiophene → 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-thiophen-2-ylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Isocyanatothiophene | HCID 2776375 | — |
| Reactant | 4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline | HCID 45379087 | — |
| Product | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-thiophen-2-ylurea | HCID 44513887 | — |
Reaction Steps
Starting from 4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)aniline (60 mg, 0.17 mmoles) and 2-thienyl isocyanate (18 mg, 0.14 mmoles), the title compound was isolated as a grey solid after Silica gel column chromatography by eluting with 5% ethyl acetate: methanol. Yield: 12 mg (14%); (M+H)=470.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575159B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-010ce40390724c21a8d1837919cb06d6 |
| Source note | uspto-grants-2013_11 |