参与物
| 角色 | 名称 | HCID | 投料 |
|---|
| 反应物 | 三乙胺 | HCID 8471 | — |
| 反应物 | 对氨基苯基乙醇 | HCID 85753 | — |
| 反应物 | 三光气 | HCID 94429 | — |
| 反应物 | 4-(4,6-二吗啡啉-1,3,5-三嗪-2-基)苯胺 | HCID 45379087 | — |
| 溶剂 | 二氯甲烷 | HCID 6344 | — |
| 产物 | [4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(1-hydroxyethyl)phenyl]urea | HCID 44515378 | 24% |
反应步骤
To a stirred mixture of 4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)aniline (0.140, 0.40 mmoles) in methylene chloride at 0° C. was added triphosgene (0.25, 0.84 mmoles) and Et3N (3 mL). The reaction mixture was stirred for 20 minutes at 0° C. Then 1-(4-aminophenyl)ethanol (0.10 g, 0.73 mmoles) was added to the mixture. The reaction mixture was stirred for about 16 hours at room temperature. The solvent was removed. The residue was dissolved in DMSO and place at HPLC using acetonitrile buffer TFA to give 48 mg (24%) of [4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(1-hydroxyethyl)phenyl]urea. M+H 506.4.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 专利号 | US08575159B2 |
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| 来源数据集 | uspto-grants-2013_11 |
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| ORD ID | ord-142be05e214540eea60263c63692f38e |
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| 来源说明 | uspto-grants-2013_11 |
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