HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 44546614, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Glycine methyl ester hydrochloride | HCID 122755 | — |
| Reactant | HCID 44548798 | HCID 44548798 | — |
| Catalyst | Triethylamine | HCID 8471 | — |
| Product | HCID 44546614 | HCID 44546614 | — |
Reaction Steps
Starting from 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(4-oxopiperidin-1-yl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea.TFA (50 mg) and glycine methyl ester hydrochloride (20 mg) and triethylamine (10 drops) and following the procedure as outlined in example 118 the title compound was isolated as its di-TFA salt after HPLC purification; MS (ES+) 574.8 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575159B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-2186270f453c4eb19a7e3d1ca1f798bd |
| Source note | uspto-grants-2013_11 |