HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylenethiourea → N-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-4,5-dihydro-1H-imidazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylenethiourea | HCID 2723650 | — |
| Reactant | 4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline | HCID 45379087 | — |
| Catalyst | Mercuric Chloride | HCID 24085 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-4,5-dihydro-1H-imidazol-2-amine | HCID 67439160 | 22% |
Reaction Conditions
| Temperature | 140 °C |
|---|
Reaction Steps
A mixture of 4-(4,6-dimorpholino-1,3,5-triazin-2-yl)aniline (40 mg, 0.12 mmol), imidazolidine-2-thione (15 mg, 0.15 mmol0 and mercury(II) chloride (40 mg, 0.15 mmol) in 2 mL of DMF was stirred at 140° C. 16 hr. Then the reaction mixture was cooled to room temperature and filtered through Celite™. The filtration was concentrated and purified by reverse phase chromatography to give N-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-4,5-dihydro-1H-imidazol-2-amine (9.0 mg, 22% yield). HPLC: Rt=1.74 min; MS 411 [M+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575159B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-dbe721ca56294e8d95b4a7e5eff47a9a |
| Source note | uspto-grants-2013_11 |