反应详情

To a mixture of 3-t-butyl-5-(4-thiophene-3-ylphenyl)-4-(2-methoxycarbonylmethyloxyphenyl)-4,5-dihydro-1H-pyrrolo[3,4-c]pyrazole-6-one (0.124 g, 0.25 mmol), THF (1.24 mL) and methanol (1.24 mL) was added 1 mol/L aqueous lithium hydroxide solution (0.74 mL), and the resulting mixture was stirred at room temperature for 1.5 hours. After the reaction was completed, 2 mol/L hydrochloric acid (0.38 mL) and water (10 mL) were poured into the reaction mixture, and the precipitated aimed compound was collected by filtration. The resulting aimed compound was dissolved in ethyl acetate, and the solution was dried over anhydrous sodium sulphate and then concentrated in vacuo. The resulting residue was triturated with ethyl ether and diisopropyl ether to give 5-(2-hydroxycarbonylmethyloxyphenyl)-4-(2,2-dimethylpropionyl)-3-hydroxy-1-(4-thiophene-3-ylphenyl)-1,5-dihydropyrrole-2-one (0.104 g, yield: 87%) as pale brown solid.

1. customthe precipitated aimed compound
2. filtrationwas collected by filtration
3. dissolutionThe resulting aimed compound was dissolved in ethyl acetate
4. dry with materialthe solution was dried over anhydrous sodium sulphate
5. concentrationconcentrated in vacuo
6. customThe resulting residue was triturated with ethyl ether and diisopropyl ether