Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1,2-Dihydroquinazolin-2-one | HCID 344381 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Quinazoline | HCID 9210 | — |
Reaction Steps
Quinazolone Z.8 (817 mg, 3.36 mmol) is combined with SOCl2 (20 mL) and DMF (0.05 mL) and heated to 80° C. for 2 h. The solvent is removed and quinazoline D*.3 (879 mg, 100%) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08575203B2 |
|---|
| Source dataset | uspto-grants-2013_11 |
|---|
| ORD ID | ord-5bf1266c1c394ca5b57cf6833a86d9fc |
|---|
| Source note | uspto-grants-2013_11 |
|---|
