HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-chloro-N-(cyclopropylmethyl)pyridine-3-carboxamide → HCID 21914628, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-chloro-N-(cyclopropylmethyl)pyridine-3-carboxamide | HCID 11275845 | — |
| Reactant | 4-Methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-(thiazol-2-yl)-benzamide | HCID 21914517 | — |
| Product | HCID 21914628 | HCID 21914628 | — |
Reaction Steps
N-Cyclopropylmethyl-6-[5-(thiazol-2-ylcarbamoyl)-2-methyl-phenyl]-nicotinamide was prepared from 6-chloro-N-cyclopropylmethylnicotinamide (Intermediate 1) and 4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-(thiazol-2-yl)-benzamide (Intermediate 11) using General Method B. LCMS: retention time 2.99 min, MH− 393. NMR: δH [2H6]-DMSO 12.71, (1H, b), 9.13, (1H, s), 8.86, (1H, t), 8.34, (1H, d), 8.21, (1H, s), 8.07, (1H, d), 7.81, (1H, d), 7.57, (1H, d), 7.52, (1H, d), 7.29, (1H, d), 3.21, (2H, t), 2.45, (3H, s), 1.07, (1H, m), 0.47, (2H, m), 0.27, (2H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575204B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-02849f0e87364d84bb3e1f7cdfaaaf3c |
| Source note | uspto-grants-2013_11 |