6-(1-Ethyl-propyl)-4-methoxy-pyridine-2-carboxylic acid → 6-(1-Ethyl-propyl)-4-methyl-pyridine-2-carboxylic acid

Participants

Reaction Steps

Methyl 6-chloro-4-methyl-pyridine-2-carboxylate (500 mg, 2.69 mmol) is treated with 1-ethyl-propyl zinkbromide and saponified as described for 6-(1-ethyl-propyl)-4-methoxy-pyridine-2-carboxylic acid to give the title compound (220 mg) as a pale yellow oil; LC-MS**: tR=0.37 min, [M+1]+=208.29; 1H NMR (CDCl3): δ 0.80 (t, J=7.3 Hz, 6H), 1.69-1.81 (m, 4H), 2.48 (s, 3H), 2.58-2.67 (m, 1H), 7.21 (s, 1H), 7.91 (s, 1H).

Provenance & Evidence